Age-Related Differences of Doublecortin Expression in the Rat’s Olfactory Bulbs
https://doi.org/10.18499/2225-7357-2017-6-3-19-24
Abstract
The aim was to study age characteristics of doublecortin (DCX) distribution in olfactory bulbs of rats ranging from 3 to 180 days of life. Material and methods. DCX, a marker of immunoreactive neuronal precursors, was detected on parasagittal sections with distribution for layers. The numerical density of the positive cells bodies (pcs/mm2) and their sizes were determined. Results. It was found that the DCX activity is noted in the bodies and in the processes of a part of the cells. The distribution density depends on the bulb layer and on the animal’s age. In newborns the density of positive neurons in the bulbs layers is small, then it increases, reaching a maximum in the mitral layer by 7th and in the granular layer - by the 14th day. In 2-month aged rats the density of neurons decreases but still exceeds the rates of newborns. The density of DCX+ cells falls to the minimum only in six-month rats. Thus, a decrease in the activity of neurogenesis according to the expression of doublecortin in the olfactory bulb in rats occurs only to the period of puberty.
About the Authors
V. E. Varentsov
Yaroslavl State Medical University, Yaroslavl, Russia
Russian Federation
Russian Federation
T. A. Rumyantseva
Yaroslavl State Medical University, Yaroslavl, Russia
Russian Federation
Russian Federation
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Review
For citations:
Varentsov V.E., Rumyantseva T.A. Age-Related Differences of Doublecortin Expression in the Rat’s Olfactory Bulbs. Journal of Anatomy and Histopathology. 2017;6(3):19-24. (In Russ.) https://doi.org/10.18499/2225-7357-2017-6-3-19-24
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