Окислительный стресс и образование NO при церулеин-индуцированном панкреатите у крыс

Взаимодействие оксида азота (NO) и супероксидных радикалов является важным механизмом развития панкреатита. В предыдущих исследованиях мы показали роль окислительного стресса и NO синтазы (NOS) в развитии хронического панкреатита человека на модели у крыс с перевязкой протока поджелудочной железы. Выявлено, что развитие окислительного стресса предшествует активации NOS. Это позволяет интерпретировать усиление продукции NO в ходе панкреатита в качестве адаптационного механизма, направленного на поддержание определенного уровня биологически активного NO в клетке. В статье представлены данные о состоянии NOS и маркеров окислительного стресса (нитротирозина и 8-гидроксигуанозина) при остром панкреатите у крыс, вызванном церулеином. Нами показано, что особенности взаимодействия супероксидных радикалов/NO в данной модели острого панкреатита аналогичным тем, которые наблюдаются при перевязке панкреатического протока, а также при хроническим панкреатите у человека. Таким образом, индуцированный церулеином пакреатит аналогичен последствиям воспаления поджелудочной железы при перевязке ее протока и является удобной моделью для дальнейших исследований патогенеза данного заболевания у человека.

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