Analysis of Tumor Volume Dynamics in Colorectal Cancer
https://doi.org/10.18499/2225-7357-2018-7-4-81-87
Abstract
The purpose of the study was to investigate the dynamics of tumor volume change in different age groups and its relation to the clinical (sex, age, stage of disease, life expectancy) and morphological parameters (tumor localization, metastases to regional lymph nodes, tumor invasion depth, histological type and degree of differentiation).
Material and methods. The data of 527 patients (men and women, age from 24 to 86 years) suffering from colorectal cancer who underwent primary resection of the tumor. Clinical data and protocols of pathologist were analyzed: clinical stage of the disease, tumor localization, life expectancy, macroscopic, microscopic description, diagnosis. Based on the data obtained from the gross description, the tumor volume was calculated.
Results. The maximum incidence of colorectal cancer was observed in patients in the age group from 70 to 79 years, more than 90% of all patients are over 50 years old. The volume of the tumor in colorectal cancer varied significantly, but the dynamics of the increase of the average volume with age was not observed. Opposite, the largest neoplasms were found in the youngest patients.
Conclusion. Obtained data shows that changes in the tumor volume in colorectal cancer is nonlinear. Indicators of tumor volume in different age groups show similar dynamics: the most common tumors are mediumsized, but the small and very large tumors are much less common, which can explain the low rates of detection of tumors of this localization in the early stages.
About the Authors
A. A. Filin
Voronezh N.N. Burdenko State Medical University
Russian Federation
Voronezh
Russian Federation
Voronezh
A. A. Sizov
Voronezh N.N. Burdenko State Medical University
Russian Federation
Voronezh
Russian Federation
Voronezh
E. E. Chupandina
Voronezh N.N. Burdenko State Medical University
Russian Federation
Voronezh
Russian Federation
Voronezh
V. I. Danilenko
Voronezh N.N. Burdenko State Medical University
Russian Federation
Voronezh
Russian Federation
Voronezh
D. Yu. Bugrimov
Voronezh N.N. Burdenko State Medical University
Russian Federation
Voronezh
Russian Federation
Voronezh
K. G. Polupanova
Voronezh N.N. Burdenko State Medical University
Russian Federation
Voronezh
Russian Federation
Voronezh
References
1. Avtandilov G.G. Osnovy kolichestvennoj patologicheskoj anatomii [Fundamentals of quantitative pathological anatomy]. M.: Medicina; 2002. 240 (in Russian).
2. Aliev V.A., Barsukov Yu. A., Nikolaev A.V. et al. Kolorektalnyj rak s sinhronnymi otdalennymi metastazami: obosnovanie citoreduktivnyh operacij i perspektivy – vzglyad hirurga [Colorectal cancer with synchronous distant metastases: rationale for cytoreductive surgery and its perspectives – a surgeons view]. Onkologicheskaya Koloproktologiya. 2012; 4: 15–21 (in Russian).
3. Kaprin A.D., Starinskij V.V., Petrova G.V. Zlokachestvennye novoobrazovaniya v Rossii v 2015 godu (zabolevaemost i smertnost) [Malignant neoplasms in Russia in 2015 (morbidity and mortality)]. М., 2017. 250 (in Russian).
4. Odincova I.N., Cheremisina O.V., Pisareva L.F., Spivakova I.O., Vusik M.V. Ehpidemiologiya kolorektalnogo raka v tomskoj oblasti [Epidemiology of colorectal cancerin Tomsk region]. Sibirskij onkologicheskij zhurnal. 2017; 16 (4): 89–95 (in Russian).
5. Osipov V.A., Abdulaev M.A., Avdeev A.M. i dr. Rezultaty hirurgicheskogo lecheniya bolnyh kolorektalnym rakom, oslozhnennym kishechnoj neprohodimostyu i krovotecheniem [Results of surgical treatment of patients with colorectal cancer complicated by intestinal obstruction and bleeding]. Vestnik of Saint Petersburg University. 2014; 3: 104–117 (in Russian).
6. Pavlova N.N., Solovev V.S. Opuholi tolstoj kishki: ehndoskopicheskaya diagnostika [Tumors of the colon: endoscopic diagnosis]. UT Research Journal. Natural Resource Use and Ecology. 2013; 6: 123–130 (in Russian).
7. Parfenov A.I. Na puti k snizheniyu rasprostranennosti kolorektalnogo raka v Moskve: ot pilotnogo issledovaniya k skriningu. Eksperimental'naia i klinicheskaia gastroenterologiia. 2011; 3: 3-5 (in Russian).
8. Filin A.A., Kozhevnikova E.E. Rol vospalitelnogo mikrookruzheniya v prognoze kolorektalnogo raka [The role of inflammatory microenvironment in the prognosis of colorectal cancer]. Prikladnye informacionnye aspekty mediciny. 2017; 20 (4): 125–129 (in Russian).
9. Homutova E.Yu., Ignatev Yu.T., Filippova Yu.G., Skripkin D.A. Vozmozhnosti virtualnoj kolonoskopii v skrininge kolorektalnogo raka i adenomatoznyh polipov [Possibilities of virtual colonoscopy in screening of colorectal cancer and adenomatous polyps]. Medical Visualization. 2009; 1: 67–75 (in Russian).
10. American Cancer Society. Cancer Facts & Figures. Atlanta, GA. 2015. 64.
11. Arnold M., Sierra M.S., Laversanne M., Soerjomataram I. et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017; 66(4): 683–691.
12. Frank S.A. Dynamics of Cancer: Incidence, Inheritance, and Evolution. Princeton (NJ): Princeton University Press; 2007.
13. Maida M., Macaluso F.S., Ianiro G., Mangiola F. et al. Screening of colorectal cancer: present and future. Expert Rev Anticancer Ther. 2017; 17(12): 1131–1146.
Review
For citations:
Filin A.A., Sizov A.A., Chupandina E.E., Danilenko V.I., Bugrimov D.Yu., Polupanova K.G. Analysis of Tumor Volume Dynamics in Colorectal Cancer. Journal of Anatomy and Histopathology. 2018;7(4):81-87. (In Russ.) https://doi.org/10.18499/2225-7357-2018-7-4-81-87
Views:
696
Email this article 