Influence of Bacteriophage Infections of Microbiota on the Expression of alpha-synuclein in the Rat Intestinal Wall
https://doi.org/10.18499/2225-7357-2018-7-4-61-66
Abstract
The aim of the study was to identify the effect of bacteriophage microbiota infection on the expression of alpha-synuclein (A-syn) in rat small intestinal wall cells.
Material and methods. The work was performed on Wistar rats, which once a day rectally injected a cocktail of bacteriophages against pathogenic bacteria or sterile saline (control). Various parts of the small intestine were frozen on dry ice, and cryostat sections were prepared to immunohistochemically investigation the localization of A-syn in the cells of the intestinal wall after 10 days of experiment.
Results. A significant quantitative increase of immunopositive to A-syn lymphocytes and an increase in the expression of this protein in the neurons of the intermuscular and submucous nerve plexuses were detected.
Conclusion. Bacteriophage infection of the microbiota has a pronounced effect on the expression of alpha synuclein in lymphocytes and neurons localized in the wall of the small intestine.
About the Authors
V. G. Sergeev
Udmurt State Univrsity; Izhevsk State Medical Academy
Russian Federation
Izhevsk
Russian Federation
Izhevsk
M. S. Tanaeva
Udmurt State Univrsity
Russian Federation
Izhevsk
Russian Federation
Izhevsk
T. N. Sergeeva
Udmurt State Univrsity
Russian Federation
Izhevsk
Russian Federation
Izhevsk
V. M. Chuchkov
Udmurt State Univrsity
Russian Federation
Izhevsk
Russian Federation
Izhevsk
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Review
For citations:
Sergeev V.G., Tanaeva M.S., Sergeeva T.N., Chuchkov V.M. Influence of Bacteriophage Infections of Microbiota on the Expression of alpha-synuclein in the Rat Intestinal Wall. Journal of Anatomy and Histopathology. 2018;7(4):61-66. (In Russ.) https://doi.org/10.18499/2225-7357-2018-7-4-61-66
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