ONTOGENESIS OF HUMAN INTERVERTEBRAL DISC
https://doi.org/10.18499/2225-7357-2018-7-1-98-107
Abstract
The aim of the work was an attempt to establish the regularities of the transition of normal age-related changes to pathological ones that determine the prevalence of degenerative diseases of the spinal column in persons of working age, economic costs and low effectiveness of treatment. The article analyzes results of foreign and domestic studies on the problem of intervertebral disc morphogenesis in humans. In this case, ontogenetic features of each intervertebral disc components are separately examined. The generalized results of cartilage endplate studies reflect the histological accessory and age-related changes in the cellular component. In the section «the ontogenesis of annulus fibrosus» features of cellular composition, structural characteristic and peculiarity of collagen fibers course in posterior and anterior parts of annulus fibrosus are described in detail, depending on the age, beginning with the embryonic period. In addition, there are differences in the structure of annulus fibrosus in the cervical, thoracic and lumbar spine. The ontogenetic features of nucleus pulposus concern the collagen fibers and their location, taking into account the age and the spinal column. Various views on the origin of the cells of the nucleus pulposus, changes in the cellular composition in the process of organism development are set forth. On the basis of a detailed analysis of the presented theoretical material, schemes reflecting the key stages of intervertebral disk embryogenesis as a whole and the morphogenesis of nucleus pulposus have been developed.
About the Authors
E. L. Kurenkov
South Ural State Medical University
Russian Federation
Russian Federation
Chelyabinsk
V. V. Makarova
South Ural State Medical University; FSHA HSMIA of Russia in Chelyabinsk region
Russian Federation
Russian Federation
Chelyabinsk
References
1. Batuev K.M. Anatomiya mezhpozvonochnyh diskov u cheloveka i nekotoryh zhivotnyh : dis. … kand. med. nauk. [Anatomy of intervertebral discs in human and some animals: cand. med. sci. diss.]. Molotov; 1954: 25-62 (in Russian).
2. But N.I. Razvitie mezhpozvonochnyh diskov v ehmbriogeneze cheloveka. Arhiv anatomii, gistologii i ehmbriologii. [Development of intervertebral discs in human embriogenesis]. 1959; 36 (3): 30-35 (in Russian).
3. Byval'cev V.A., Belyh E.G., Alekseeva N.V. i dr. Primenenie shkal i anket v obsledovanii patsientov s degenerativnym porazheniem poyasnichnogo otdela pozvonochnika: metodicheskie rekomendacii. [The use of scales and questionnaires in the evaluation of patients with degenerative diseases of lumbar spine: guidelines.] Irkutsk: FBSI SCRRS SD RAMS; 2013. 32 (in Russian).
4. Degtyarev I.P. Vozrastnye morfologicheskie izmeneniya pul'poznogo yadra poyasnichnyh mezhpozvonkovyh diskov cheloveka. Patologiya pozvonochnika: mater. II Novosibirskoj konf. po lecheniyu zabolevanij i povrezhdenij pozvonochnika. [Age-related morphological changes of human lumbar intervertebral discs nucleus pulposus. Patology of spine: The materials of II Novosibirsk conference on treatment of spine diseases and injuries.] Novosibirsk; 1966: 229-230 (in Russian).
5. Degtyarev I.P. Vozrastnye morfologicheskie izmeneniya fibroznogo kol'ca poyasnichnyh mezhpozvonkovyh diskov cheloveka. Patologiya pozvonochnika: mater. II Novosibirskoj konf. po lecheniyu zabolevanij i povrezhdenij pozvonochnika. [Age-related morphological changes of human lumbar intervertebral discs anulus fibrous. Patology of spine: The materials of II Novosibirsk conference on treatment of spine diseases and injuries]. Novosibirsk; 1966: 224-226 (in Russian).
6. Degtyarev I.P. Morfologicheskoe i gistohimicheskoe izuchenie hryashchevoj plastinki poyasnichnyh mezhpozvonkovyh diskov cheloveka. Patologiya pozvonochnika: mater. II Novosibirskoj konf. po lecheniyu zabolevanij i povrezhdenij pozvonochnika. [Age-related morphological changes of human lumbar intervertebral discs cartilaginous endplate. Patology of spine: The materials of II Novosibirsk conference on treatment of spine diseases and injuries]. Novosibirsk; 1966: 233-235 (in Russian).
7. Pavlova V.N., Kop'eva T.N., Sluckij L.I. i dr. Hryashch. [Cartilage]. M.: Medicina; 1988. 320 (in Russian).
8. Strukov A.I. Vozrastnoe razvitie pozvonochnogo stolba. V kn.: Shurpe Eh.Yu., red. Anatomicheskie i gistostrukturnye osobennosti detskogo vozrasta: tr. lab. vozrastnoj morfologii gos. cent. in-ta ohrany zdorov'ya detej i podrostkov NKZ. [Agerelated development of spinal column. In book: Shurpe E.Y., edited by. Anatomical and histostructural features of childhood. Publications of agerelated morphology laboratory of the State Institute for health protection of children and adolescents]. M.: Biomedgiz; 1936: 55-123 (in Russian).
9. Antoniou J., Steffen T., Nelson F. et al. The human lumbar intervertebral disc. Evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J. Clin. Invest. 1996; 98 (4): 996-1003. DOI: 10.1172/JCI118884.
10. Bron J.L., Helder M.N., Meisel H.-J. Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges. Eur. Spine J. 2009; 18 (3): 301-313. DOI: 10.1007/s00586008-0856-x.
11. Cortes D.H., Han W. M., Smith L. et al. Mechanical properties of the extra-fibrillar matrix of human annulus fibrosus are location and age dependent. J. Orthop. Res. 2013; 31 (11): 1725-1732. DOI: 10.1002/jor.22430.
12. Feng Y., Egan B., Wang J. Genetic factors in intervertebral disc degeneration. Genes Dis. 2016; 3 (3): 178-185. DOI: 10.1016/j.gendis.2016.04.005.
13. Kadow T., Sowa G., Vo N. et al. Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions? Clin. Orthop. Relat. Res. 2015; 473 (6): 1903-1912. DOI: 10.1007/s11999-014-3774-8.
14. McCann M.R., Séguin C.A. Notochord cells in intervertebral disc development and degeneration. J. Dev. Biol. 2016; 4 (1): 1-18. DOI: 10.3390/jdb4010003.
15. Naylor A. The biophysical and biochemical aspects of intervertebral disc herniation and degeneration. Ann. Roy. Coll. Surg. Engl. 1962; 31 (2): 91-114.
16. Pattappa G., Li Z., Peroglio M., Wismer N. et al. Diversity of intervertebral disc cells: phenotype and function. Journal of Anatomy. 2012; 221: 480496. DOI: 10.1111/j.1469-7580.2012.01521.x.
17. Peacock A. Observations of prenatal structure of the intervertebral disc in man. Journal of Anatomy. 1951; 85 (Pt. III): 260-274.
18. Roberts S. Disc morphology in health and disease. Biochemical society transaction. 2002; 30 (6): 864-869. DOI: 10.1042/bst0300864.
19. Sive J. I., Baird P., Jeziorsk M. et al. Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. J. Clin. Pathol.: Mol. Pathol. 2002; 55: 91-97.
20. Smith L. J., Nerurkar N. L., Choi K.-S. et al. Degeneration and regeneration of the intervertebral disc: lessons from development. Disease Models & Mechanisms. 2011; 4 (1): 31-41. DOI: 10.1242/dmm.006403.
21. Trout J. J., Buckwalter J. A., Moore K. C. et al. Ultrastructure of human intervertebral disc. I. Changes in notochordal cells with age. Tissue Cell. 1982; 14 (2): 359-369.
22. Vo N. V., Hartman R. A., Patil P. R. et al. Molecular mechanisms of biological aging in intervertebral discs. J. Orthop. Res. 2016; 34 (8): 12891306. DOI: 10.1002/jor.23195.
23. Weiler C., Nerlich A.G., Schaaf R. et al. Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc. Eur. Spine J. 2010; 19 (10): 1761-1177. DOI: 10.1007/s00586-010-1392-z.
24. Wyburn G.M. Observations on development of the human vertebral column // Journal of Anatomy. 1944. Vol. 78 (Pt. III). P. 94-102.2.
25. Zhu Q., Gao X., Gu W. Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression. J. Biomech. 2014; 47 (15): 37343743. DOI: 10.1016/j.jbiomech.2014.09.004.
Review
For citations:
Kurenkov E.L., Makarova V.V. ONTOGENESIS OF HUMAN INTERVERTEBRAL DISC. Journal of Anatomy and Histopathology. 2018;7(1):98-107. (In Russ.) https://doi.org/10.18499/2225-7357-2018-7-1-98-107
Views:
449
Email this article 