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RUSSIA MORPHOMETRIC ANALYSIS OF RESPONSE OF THE ADRENAL MEDULLA TO PARTIAL LASER DESTRUCTION OF THE CONTRALATERAL ORGAN

https://doi.org/10.18499/2225-7357-2018-7-1-62-67

Abstract

The purpose of the study was to identify the morphometric response of the rat adrenal medulla to partial laser destruction of the contralateral organ.

Materials and methods. On paraffin sections of adrenal medulla stained using L.H. Honore method in Wistar rats (n=41) for 2 months after the laser damage of the contralateral organs the volume fractions of adrenalocytes, noradrenalocytes, blood vessels, stroma and neurons were determined as well as the average crosssectional areas of adrenalocytes, noradrenalocytes and their nuclei.

Results. In the intact adrenal medulla after partial laser destruction of the contralateral organ, we found an increase in the volume fraction of blood vessels on day 7. This coincides with the increase in the vascular fraction in the damaged paired organ at this time. There are also detected a change of ratio adrenalocytes : noradrenalocytes in favor of the first in the course of the entire observation. Besides, we identified hypertrophy in the both subpopulations of chromaffinocytes and in their nuclei with maximum on day 14. More pronounced the hypertrophy was in the adrenalocytes than in the noradrenalocytes.

Conclusions. The systemic response of the adrenal medulla as the connected paired structure manifested itself in the increase of the volume fraction of blood vessels in both adrenal medulla on day 7 after laser lesion of one of them. Compensatory-adaptive reaction manifested in hypertrophy of the both subpopulations of chromaffinocytes and their nuclei with maximum on day 14. Change of ratio adrenalocytes : noradrenalocytes in favor of the first in the course of the entire observation also can be considered as a consequence of the compensatoryadaptive system response of adrenal medulla on this type of impact.

About the Authors

K. G. Kemoklidze
Yaroslavl State Medical University
Russian Federation


N. A. Tyumina
Yaroslavl State Medical University
Russian Federation


References

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Review

For citations:


Kemoklidze K.G., Tyumina N.A. RUSSIA MORPHOMETRIC ANALYSIS OF RESPONSE OF THE ADRENAL MEDULLA TO PARTIAL LASER DESTRUCTION OF THE CONTRALATERAL ORGAN. Journal of Anatomy and Histopathology. 2018;7(1):62-67. (In Russ.) https://doi.org/10.18499/2225-7357-2018-7-1-62-67

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