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Journal of Anatomy and Histopathology

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Evaluation of microcirculation in tissues of skin regenerate using ultrasound dopplerography

https://doi.org/10.18499/2225-7357-2017-6-4-59-62

Abstract

The aim is to study microcirculation in the skin tissues regenerate using Doppler ultrasound. Material and methods. In an experiment on laboratory white female rats, the effect of the angiovascular drug Neovasculgen on the repair of a full-thickness skin wound was studied. To assess the state of the microcirculatory bed of the regenerating granulation tissue of the regenerate, the ultrasound computerized device Minimax-Doppler-K was used. The processing dopplerograms obtained average systolic blood flow linear velocity, the mean systolic volumetric blood flow rate were calculated pulsation index, peripheral resistance. The data were processed by nonparametric statistics. Results. With the use of an angioactive drug, the volumetric flow velocity is increased, indicating a better blood supply in the area of the regenerating wound. The average systolic linear velocity of blood flow also increases, which is associated with vascular reduction. The indicators of the index of pulsation and peripheral resistance are reduced. Data on the linear and volume velocities of the blood flow made it possible to reveal elevated, in comparison with the control, indicators of the total cross-section of microvessels and the amount of blood entering the region of the regenerate under conditions of stimulated angiogenesis. Conclusion. Doppler examination allows to evaluate the course of all stages of the healing process, in the screening mode to monitor the microcirculatory bed in the regenerate area, to predict and correct the healing process.

About the Author

V. G. Shestakova
Tver State Medical University, Tver, Russia
Russian Federation


References

1. Богданова Э. А. Применение метода лазерной допплеровской флоуметрии в кардиологии. Метод. разработка под общ. ред. В.И. Маколкина. Москва, 1998.

2. Козлов В. И. Лазерная допплеровская флоуметрия и анализ коллективных процессов в системе микроциркуляции. Физиология человека. 1998; 6: 112-121.

3. Лоскутова З. Ф. Виварий. М.: Медицина, 1980: 15.

4. Ступникова О. Н. Метод лазерной допплеровской флоуметрии и его возможности в оценке изменений микроциркуляции суставов при ревматоидном артрите. Сибирский медицинский журнал. 2007; 2: 14-18.

5. Халепо О. В. Использование метода лазерной доплеровской флоуметрии для оценки роли микроциркуляторных нарушение при патологии (клинико-экспериментальное исследование). Вест. восст. мед-ны. 2008; 3(25): 64-67.

6. Шестакова В. Г., Банин В. В., Баженов Д. В. Морфологическое и допплерографическое изучение кровоснабжения регенерата кожи в условиях стимулированного ангиогенеза. Актуальные вопросы фундаментальной, экспериментальной и клинической морфологии: материалы Всероссийской конференции молодых специалистов. Рязань: ООП УИТТиОП, 2017. 73-76.

7. Hosoda G. Laser Doppler flowmetry for the early detection of hypertrophic burn scars. Int. Wound J. 2013; 10(5): 597-605.


Review

For citations:


Shestakova V.G. Evaluation of microcirculation in tissues of skin regenerate using ultrasound dopplerography. Journal of Anatomy and Histopathology. 2017;6(4):59-62. (In Russ.) https://doi.org/10.18499/2225-7357-2017-6-4-59-62

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ISSN 2225-7357 (Print)