Comparative characteristics of the white rats neocortex, hippocampus and amygdale complex synaptoarchitectonics in norm and after acute ischemia

The aim of this study was to interneuronal synapses and mitochondria somatosensory cortex (SSC), CA1 of the hippocampus and the central nucleus of the amygdaloid complex (MC) of the brain of albino rats (n=35) after a 20-minute bilateral occlusion of common carotid arteries. Material and methods. Used electron microscopy, morphometric and statistical methods. Ultrathin sections were contrasted by uranyl acetate and analyzed by lead citrate, and phosphonoformate acid. Results. After 3 days after ischemia the total number density of contacts (TNDC) in the SSC declined by 55.2, CA1 hippocampus - 44.8, and MC - 26.7%. The restoration of TNDC in SSC and CA1 of the hippocampus to control levels occurred in 21 and 30 days, and in MC - in 14 days. Deficit TNDC in the postischemic period depended on the number of synapses and square slices of mitochondria per unit field of view in the studied parts of the brain to ischemia (norm). Conclusions. The smaller the number of synapses and the larger the area of mitochondria in normal, the less damaged synapses after ischemia.

крыса, реперфузия, неокортекс, гиппокамп, миндалевидный комплекс, синапсы, митохондрии, ультраструктура, морфометрия, rat, reperfusion, neocortex, hippocampus, amygdaloid complex, synapses, mitochondria, ultrastructure, morphometry

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