Experimental Model of Sudden Cardiac Death Morphogenesis in Hyperandrogenaemia
https://doi.org/10.18499/2225-7357-2016-5-4-90-96
Abstract
The paper summarizes the literature data on the effect of testosterone and its synthetic derivatives on athletes. Biosynthetic pathways and metabolism of testosterone, testosterone signaling pathway, its main biological effects have been characterized. The main attention is paid to the problems of hypo- and hyperandrogenaemia as the two extreme manifestations of deviation from the physiological level of testosterone in the blood of men. Therefore prospects for further studies were identified: hyperandrogenism influence on the heart muscle in athletes and in men who use natural or synthetic analogs of testosterone as a means of increasing physical endurance and activity.
About the Authors
Zh. R. Omarova
N. I. Pirogov Russian National Research Medical University, Moscow, Russia
Russian Federation
Russian Federation
V. V. Filatov
N. I. Pirogov Russian National Research Medical University, Moscow, Russia
Russian Federation
Russian Federation
M. V. Mnikhovich
N. I. Pirogov Russian National Research Medical University, Moscow, Russia; Research Institute of Human Morphology, Moscow, Russia
Russian Federation
Russian Federation
L. V. Kakturskiy
N. I. Pirogov Russian National Research Medical University, Moscow, Russia; Research Institute of Human Morphology, Moscow, Russia
Russian Federation
Russian Federation
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Review
For citations:
Omarova Zh.R., Filatov V.V., Mnikhovich M.V., Kakturskiy L.V. Experimental Model of Sudden Cardiac Death Morphogenesis in Hyperandrogenaemia. Journal of Anatomy and Histopathology. 2016;5(4):90-96. (In Russ.) https://doi.org/10.18499/2225-7357-2016-5-4-90-96
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