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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">anatomy</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал анатомии и гистопатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Anatomy and Histopathology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2225-7357</issn><publisher><publisher-name>N.N. Burdenko Voronezh State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18499/2225-7357-2016-5-4-90-96</article-id><article-id custom-type="elpub" pub-id-type="custom">anatomy-331</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>МОРФОГЕНЕЗ ВНЕЗАПНОЙ СЕРДЕЧНОЙ СМЕРТИ ПРИ ГИПЕРАНДРОГЕНЕМИИ НА ЭКСПЕРИМЕНТАЛЬНОЙ МОДЕЛИ</article-title><trans-title-group xml:lang="en"><trans-title>Experimental Model of Sudden Cardiac Death Morphogenesis in Hyperandrogenaemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Омарова</surname><given-names>Жанна Рубеновна</given-names></name><name name-style="western" xml:lang="en"><surname>Omarova</surname><given-names>Zh. R.</given-names></name></name-alternatives><email xlink:type="simple">ganu82@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филатов</surname><given-names>Владимир Васильевич</given-names></name><name name-style="western" xml:lang="en"><surname>Filatov</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мнихович</surname><given-names>Максим Валерьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Mnikhovich</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кактурский</surname><given-names>Лев Владимирович</given-names></name><name name-style="western" xml:lang="en"><surname>Kakturskiy</surname><given-names>L. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России<country>Россия</country></aff><aff xml:lang="en">N. I. Pirogov Russian National Research Medical University, Moscow, Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России; ФГБНУ «Научно-исследовательский институт морфологии человека»<country>Россия</country></aff><aff xml:lang="en">N. I. Pirogov Russian National Research Medical University, Moscow, Russia; Research Institute of Human Morphology, Moscow, Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2017</year></pub-date><volume>5</volume><issue>4</issue><fpage>90</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Омарова Ж.Р., Филатов В.В., Мнихович М.В., Кактурский Л.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Омарова Ж.Р., Филатов В.В., Мнихович М.В., Кактурский Л.В.</copyright-holder><copyright-holder xml:lang="en">Omarova Z.R., Filatov V.V., Mnikhovich M.V., Kakturskiy L.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://anatomy.elpub.ru/jour/article/view/331">https://anatomy.elpub.ru/jour/article/view/331</self-uri><abstract><p>В работе обобщены данные литературы о влиянии тестостерона и его синтетических производных на организм спортсменов. Охарактеризованы пути биосинтеза и метаболизма тестостерона, сигнальный путь тестостерона, его основные биологические эффекты. Основное внимание уделено проблемам гипо- и гиперандрогенемии, как двум крайним проявлениям отклонения от физиологического уровня тестостерона в крови у мужчин. В связи с этим были определены перспективы дальнейших исследований: влияние гиперандрогенемии на сердечную мыщцу у спортсменов и мужчин, использующих природные и синтетические аналоги тестостерона в качестве средств повышающих физическую выносливость и активность.</p></abstract><trans-abstract xml:lang="en"><p>The paper summarizes the literature data on the effect of testosterone and its synthetic derivatives on athletes. Biosynthetic pathways and metabolism of testosterone, testosterone signaling pathway, its main biological effects have been characterized. The main attention is paid to the problems of hypo- and hyperandrogenaemia as the two extreme manifestations of deviation from the physiological level of testosterone in the blood of men. Therefore prospects for further studies were identified: hyperandrogenism influence on the heart muscle in athletes and in men who use natural or synthetic analogs of testosterone as a means of increasing physical endurance and activity.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>внезапная сердечная смерть</kwd><kwd>гиперадрогенемия</kwd><kwd>спортсмены</kwd><kwd>анаболики</kwd><kwd>кардиомиоциты</kwd><kwd>sudden cardiac death</kwd><kwd>hyperandrogenaemia</kwd><kwd>athletes</kwd><kwd>anabolic steroids</kwd><kwd>cardiomyocytes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бехтерева Н. П. Физиология эндокринной системы / Н.П. Бехтерева. 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