Нemodynamic and Morphological Preconditions of Cerebrovascular Pathology Development

Abstract

Relevance of the study is explained by a high mortality due to complications of cerebrovascular pathology. Material for the study was the circle of Willis of 467 people (0-85 years) who died from causes not related with the disturbance of cerebral circulation and didn’t suffer from hypertension, diseases of connective tissue and diabetes. CT scans of 100 patients (17-85 years) with cerebrovascular disease were examined. Methods: macroscopic, CT, histological, histochemical, immunohistochemical, morphometric, physical modeling of blood flow with glass models which correspond to the structure of circle of Willis vessels, mathematical and statistical modeling. Features of blood vessels in the circle of Willis, which promote changes in the arterial wall over the range of human life, which can lead to the development of cerebral circulatory disorders are established. Risk of aneurysm in vessels of circle of Willis developing exists from the age of 30-35 years (considerable thinning of the tunica media), in areas where a lot of vascular branching and artery are divided into different diameter secondary vessels, with a counterflow and in non-classical variants of the structure of circle. Increasing of intimal thickness in angles of vascular bifurcation of circle of Willis which contribute of stenosis of cerebral blood vessels has occurred after 56 years.