Characteristics of Functional State of Rats’ Placenta with Experimental Chronic liver Disease of Various Origins

Abstract

The relevance of research is determined by the important role of maternal health in solving the problem of reproduction of full posterity. Numerous studies have confirmed the role of liver disease in the formation of the physiological immaturity of the offspring. The aim of the study was to analyze the functional state in rats with experimental chronic liver disease due to the fact that the optimal development of the fetus is largely determined by the condition of the placenta. In some animals liver damage was induced by subcutaneous injection of 0.1 ml of a 40% oil solution of carbon tetrachloride two times a week for 2 months. Another group of animals was administered intragastric for two days at a dose of paracetamol of 2.5 g/kg of body weight. Proliferative, anti-apoptotic and proapoptotic activity and membrane permeability of trophoblast of different compartments studied by using immunohistochemistry and biological methods. Analysis of the characteristics of the functional state of the placenta of rats with experimental chronic toxic and drug liver disease allowed to establish reducing of proliferative and anti-apoptotic activity and increasing of pro-apoptotic activity of the placental cells of different compartments. In addition, it was found that chronic liver pathology in experiment leads to increasing of permeability of the membranes of the placental barrier that may indicate in our opinion the development of placental insufficiency.