The Features of the Connective Tissue Morphological Change During a Skin Scar Formation After a Cesarean Section
https://doi.org/10.18499/2225-7357-2021-10-1-49-53
Abstract
During a skin scar formation morphofunctional change of skin structures takes place. The action of external mechanical factors can lead to prolongation of reparative processes in the scar and to the change in the morphometric parameters of its components.
Research goal: to study the features of the skin structural components morphological change in secundipara women during a connective tissue scar formation after a cesarean section.
Material and methods. The materials for the study were the fragments of a connective tissue scar with an adjacent area of intact skin taken from 30 women after operative delivery by Caesarean section. On scanning electron microscopy, morphometric parameters were measured, which enabled to assess the cell composition and the changes in the fibrous components of the connective tissue scar.
Results. Analyzing the thickness of the fibers in the same age group, the thickening of the fibers was observed in direct proportion to the number of births. Comparing different age groups with the same number of births, the thinning of collagen fibers was observed. The most pronounced changes were observed in women having three or more deliveries.
Conclusion. Under the influence of the stretching force in the skin, a structural change of the connective tissue scar occurs. This change is due to the thickening of collagen structures, the decrease in the density of collagen structures location, the increase in the number of lymphocytes and macrophages.
About the Authors
E. S. Mishina
Kursk State Medical University
Russian Federation
Russian Federation
Ekaterina Mishina
ul. K. Marksa, 3, Kursk, 305000
M. A. Zatolokina
Kursk State Medical University
Russian Federation
Russian Federation
Kursk
References
1. Гаспаров А.C., Дубинская Е.Д., Бабичева И.A., Лаптева Н.B. Роль дисплазии соединительной ткани в акушерско-гинекологической практике. Казанский медицинский журнал. 2014;95(6):897–904 [Gasparov AS, Dubinskaya ED, Babicheva IA, Lapteva NV, Dorfman MF. Role of Connective Tissue Dysplasia in Obstetrics and Gynecology Kazan medical journal. 2014;95(6):897–904] (in Russian).
2. Зорина А.И., Бозо И.Я., Зорин В.Л., Черкасов В.Р., Деев Р.В. Фибробласты дермы: особенности цитогенеза, цитофизиологии и возможности клинического применения. Гены и клетки. 2011;VI(2):15–26 [Zorina AI, Bozo IYa, Zorin VL, Cherkasov VR, Deev RV. Derma Fibroblasts: Peculiarities of Cytogenesis, Histophysiology and Possible Clinical Use. Genes and Cells. 2011;VI(2):15–26] (in Russian).
3. Мишина Е.С., Затолокина М.А., Сергеева С.Ю. Изучение факторов динамического структурирования коллагеновых волокон в эксперименте. Морфология. 2019;11(2):199 [Mishina YeS, Zatolokina MA, Sergeyeva SYu. The Study of the Factors of Dynamic Structuring of Collagen Fibers in the Experiment. Morphology. 2019;11(2):199] (in Russian).
4. Омельяненко Н.П., Слуцкий Л.И. Соединительная ткань (гистофизиология и биохимия). Акад. РАН и РАМН Миронов С.П., ред. М.: Известия; 2009 [Omel'yanenko N.P., Slutskii L.I. Soedinitel'naya tkan' (gistofiziologiya i biokhimiya). Akad. RAN i RAMN Mironov S.P., red. M.: Izvestiya; 2009] (in Russian).
5. Шевлюк Н.Н., Гатиатуллин И.З., Стадников А.А. Особенности репаративных гистогенезов при использовании биопластических материалов. Журнал анатомии и гистопатологии. 2020;9(1):86–93 [Shevlyuk NN, Gatiatullin IZ, Stadnikov AA. Features of Reparative Histogenesis in Bioplastic Material Application. Journal of Anatomy and Histopathology. 2020 Apr 1;9(1):86–93] (in Russian). doi: 10.18499/2225-7357-2020-9-1-86-93
6. Calì G, Timor-Tritsch IE, PalaciosJaraquemada J, Monteaugudo A, Buca D, Forlani F, et al. Outcome of Cesarean scar pregnancy managed expectantly: systematic review and meta-analysis. Ultrasound in Obstetrics & Gynecology. 2018 Feb;51(2):169–75. doi: 10.1002/uog.17568
7. Davidson C, Bellows P, Shah U, Hawley L, Drexler K, Gandhi M, et al. Outcomes associated with trial of labor after cesarean in women with one versus two prior cesarean deliveries after a change in clinical practice guidelines in an academic hospital*. The Journal of Maternal-Fetal & Neonatal Medicine. 2019 Feb 6;33(9):1499–504. doi: 10.1080/14767058.2018.1520831
8. Rittié L. Fibrosis : methods and protocols. New York: Humana Press; 2017.
9. Ghazanfari S, Khademhosseini A, Smit TH. Mechanisms of lamellar collagen formation in connective tissues. Biomaterials. 2016 Aug;97:74– 84. doi: 10.1016/j.biomaterials.2016.04.028
10. Harris JR, Lewis RJ. The collagen type I segment long spacing (SLS) and fibrillar forms: Formation by ATP and sulphonated diazo dyes. Micron. 2016 Jul;86:36–47. doi: 10.1016/j.micron.2016.04.008
11. Kwon J-W, Lee W-J, Park S-B, Kim MJ, Jang SH, Choi CK. Generalized Joint Hypermobility in Healthy Female Koreans: Prevalence and AgeRelated Differences. Annals of Rehabilitation Medicine. 2013;37(6):832–38. doi: 10.5535/arm.2013.37.6.832
12. Korgavkar K, Wang F. Stretch marks during pregnancy: a review of topical prevention. British Journal of Dermatology. 2015 Feb 8;172(3):606– 15. doi: 10.1111/bjd.13426
13. Moalli PA, Shand SH, Zyczynski HM, Gordy SC, Meyn LA. Remodeling of Vaginal Connective Tissue in Patients With Prolapse. Obstetrics & Gynecology. 2005 Nov;106(5, Part 1):953–63. doi: 10.1097/01.aog.0000182584.15087.dd
14. Ram M, Hiersch L, Ashwal E, Yogev Y, Aviram A. Trial of labor after previous single cesarean delivery in grand-multiparous women: a retrospective cohort study. Archives of Gynecology and Obstetrics. 2021 Jan 3. doi: 10.1007/s00404-020-05946-z
15. Rawlings AV, Bielfeldt S, Lombard KJ. A review of the effects of moisturizers on the appearance of scars and striae. International Journal of Cosmetic Science. 2012 Sep 21;34(6):519–24. doi: 10.1111/j.1468-2494.2012.00751.x
16. Valère MK, Etienne B, Phelix Adolphe E, Brice TF, Tebeu PM. The Mode of delivery of grand multiparous with post-cesarean single uterine scar in low resources settings: A retrospective cohort study. European Journal of Obstetrics & Gynecology and Reproductive Biology: X. 2019 Oct;4:100078. doi: 10.1016/j.eurox.2019.100078
Review
For citations:
Mishina E.S., Zatolokina M.A. The Features of the Connective Tissue Morphological Change During a Skin Scar Formation After a Cesarean Section. Journal of Anatomy and Histopathology. 2021;10(1):49-53. (In Russ.) https://doi.org/10.18499/2225-7357-2021-10-1-49-53
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