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Патоморфологические и молекулярно-биологические аспекты повреждения кровеносных сосудов при COVID-19

https://doi.org/10.18499/2225-7357-2020-9-4-9-18

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Аннотация

Коронавирусная инфекция COVID-19, вызванная SARS-CoV-2, связана не только с широким спектром респираторных синдромов, но и с выраженным деструктивным влиянием на кровеносные сосуды всего организма. Возраст и сопутствующая патология, предрасполагают к более тяжелому течению заболевания. В качестве общих неспецифических патоморфолологических изменений, развивающихся в кровеносных сосудах под влиянием SARS-CoV-2, можно выделить повреждение эндотелия, распространенные васкулиты и тромбозы. Для кровеносных сосудов легких помимо альтерации эндотелия и тромбоза был характерен ангиогенез по расщепляющему (инвагинационному) типу. Общим механизмом альтерации кровеносных сосудов и развития васкулопатий является прямое цитопатическое воздействие вируса на эндотелиоциты и иммуноопосредованное повреждение эндотелия, проявляющееся развитием эндотелиита, деструкцией межклеточных контактов эндотелиальных клеток, их набухаением и разобщением с базальной мембраной, сопровождающееся эндо- и периваскулярным воспалением. Молекулярно-биологические механизмы инвазии вируса вовлекают различные пути его проникновения в клетку и разнообразные формы развития воспалительного ответа с участием реакций врожденного и приобретенного иммунитета.

Об авторах

И. Э. Есауленко
ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России
Россия
Воронеж


Д. Б. Никитюк
ФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)
Россия
Москва


Н. Т. Алексеева
ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России
Россия
Воронеж


А. А. Шевченко
БУЗ ВО «Воронежская городская клиническая больница скорой медицинской помощи №1»
Россия
Воронеж


Д. А. Соколов
ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России
Россия

Соколов Дмитрий Александрович

ул. Студенческая, 10, Воронеж, 394036



С. В. Клочкова
ФГАОУ ВО «Российский университет дружбы народов»; ГАУЗ «Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины ДЗМ»
Россия
Москва


А. Г. Кварацхелия
ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России
Россия
Воронеж


А. А. Филин
ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России
Россия
Воронеж


В. А. Тутельян
ФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»
Россия
Москва


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Рецензия

Для цитирования:


Есауленко И.Э., Никитюк Д.Б., Алексеева Н.Т., Шевченко А.А., Соколов Д.А., Клочкова С.В., Кварацхелия А.Г., Филин А.А., Тутельян В.А. Патоморфологические и молекулярно-биологические аспекты повреждения кровеносных сосудов при COVID-19. Журнал анатомии и гистопатологии. 2020;9(4):9-18. https://doi.org/10.18499/2225-7357-2020-9-4-9-18

For citation:


Esaulenko I.E., Nikityuk D.B., Alexeeva N.T., Shevchenko A.A., Sokolov D.A., Klochkova S.V., Kvaratskheliya A.G., Filin A.A., Tutel'yan V.A. Pathomorphological and Molecular Biological Aspects of Blood Vessel Injury in COVID-19. Journal of Anatomy and Histopathology. 2020;9(4):9-18. (In Russ.) https://doi.org/10.18499/2225-7357-2020-9-4-9-18

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