Structural Changes in the Lung of Rats as the Result of the Aerosol Inhalation of Non-nicotine Liquid Used for Electronic Cigarettes
https://doi.org/10.18499/2225-7357-2016-5-2-41-45
Abstract
The article describes morphological changes of the lung tissue of Vistar rats. These changes were caused by the inhalation of non-nicotine liquid used for electronic cigarettes. The changes were studied in acute, subacute and chronic periods. Histological research has shown that the experimental group of rats has the swelling of the alveolar septa, interchanging areas of atelectasis and emphysema during the acute period. During the subacute period swelling of the alveolar septa remains present. A number of atelectasis of the alveoli decreased due to the increase of the emphysematous expansion of the alveoli. Chronic period is characterized by emphysema: increase in terminal and respiratory bronchioles as well as in alveolar cavity with thinning of the alveolar septa.
About the Authors
V. S. Pikalyuk
V. I. Vernadsky Crimean Federal University, Simferopol, Russia
Russian Federation
Russian Federation
V. V. Shalanin
V. I. Vernadsky Crimean Federal University, Simferopol, Russia
Russian Federation
Russian Federation
E. A. Zhuravel'
V. I. Vernadsky Crimean Federal University, Simferopol, Russia
Russian Federation
Russian Federation
Z. V. Asanova
V. I. Vernadsky Crimean Federal University, Simferopol, Russia
Russian Federation
Russian Federation
References
1. Борьба с бездымными табачными изделиями и электронными сигаретами и предупреждение их употребления. Доклад Секретариата Конвенции. Четвертая сессия. Пунта-дель-Эсте, Уругвай, 15-20 ноября 2010. 9 с.
2. Коржевский Д. Э. Основы гистологической техники / Д.Э. Коржевский, А.В. Гиляров. СПб: Изд. СпецЛит, 2010. 95 с.
3. Михина Л. И. Подходы к гигиенической оценке изделия «электронная сигарета» как потенциального источника загрязнения воздуха помещений жилых и общественных зданий / Л.И. Михина // Здоровье и окружающая среда. 2013. №22. С.185-187.
4. Оганов Р. Г. Табак и здоровье: мирное сосуществование невозможно: Европейская конференция ВОЗ на уровне министров “За Европу без табака”, Варшава, 18-19 февраля, 2002. С. 27.
5. Электронные системы доставки никотина, включая электронные сигареты. Доклад Секретариата Конвенции. Пятая сессия, Сеул, Республика Корея, 12-17 ноября, 2012. 14 с.
6. Электронные системы доставки никотина. Доклад ВОЗ. Шестая сессия, Москва, Российская Федерация, 13-18 октября, 2014. 20 с.
7. Bahl V. Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models / V. Bahl [et al.] // Reprod Toxicol. 2012. №34. Р. 529-537.
8. Chen I. FDA summary of adverse events on electronic cigarettes / I. Chen // Nicotine Tob Res. 2013. №15. Р. 615-616.
9. Farsalinos K. E. Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells / KE. Farsalinos [et al.] // International Journal of Environmental Research and Public Health. 2013. №10. Р. 5146-5162.
10. Flouris A. Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function / A. Flouris [et al.] // Inhalation Toxicology. 2013. №25. Р. 91-101.
11. Henderson T. Heat degradation studies of solar heat transfer fluids / T. Henderson [et al.] // Solar Energy. 1981. №27. Р. 121-128.
12. Laino T. Mechanisms of propylene glycol and triacetin pyrolysis / T. Laino [et al.] // The journal of physical chemistry. 2012. №116. Р. 4602-4609.
13. McAuley T. Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality / T. McAuley [et al.] // Inhalation Toxicology. 2012. №24. P. 850-857.
14. Romagna G. Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract / G. Romagna [et al.] // Inhalation Toxicology. 2013. №25. Р. 354-361.
15. Schober W. Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers / W. Schober [et al.] // International Journal of Hygiene and Environmental Health. 2014. № 217. Р. 628-637.
16. Schripp T. Does e-cigarette consumption cause passive vaping? / T. Schripp [et al.] // Indoor Air. 2013. №23. Р. 25-31.
17. Vardavas C. Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impedance, and exhaled nitric oxide / С. Vardavas [et al.] // Chest. 2012. №141. P. 1400-1406.
Review
For citations:
Pikalyuk V.S., Shalanin V.V., Zhuravel' E.A., Asanova Z.V. Structural Changes in the Lung of Rats as the Result of the Aerosol Inhalation of Non-nicotine Liquid Used for Electronic Cigarettes. Journal of Anatomy and Histopathology. 2016;5(2):41-45. (In Russ.) https://doi.org/10.18499/2225-7357-2016-5-2-41-45
Views:
551
Email this article 