anatomyЖурнал анатомии и гистопатологииJournal of Anatomy and Histopathology2225-7357N.N. Burdenko Voronezh State Medical University10.18499/2225-7357-2016-5-3-84-89anatomy-307Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESРоль нарушения клеточно-матриксных взаимодействий в патогенезе прогрессирования фиброза легкихThe Role of the Disorders of Cell Matrix Interactions in the Pathogenesis of Pulmonary Fibrosis ProgressionХоринкоАндрей ВитальевичKhorinkoA. V.noemail@neicon.ruАмарантовДмитрий ГеоргиевичAmarantovD. G.noemail@neicon.ruКосареваПолина ВладимировнаKosarevaP. V.noemail@neicon.ruГБУЗ ПК «Пермский краевой онкологический диспансер»Perm Territorial Oncology Dispensary, Perm, RussiaГБОУ ВПО «Пермский государственный медицинский университет им. акад. Е. А. Вагнера» Минздрава РФPerm State Medical University named after E. A. Wagner, Perm, Russia201628122017538489Copyright © Хоринко А.В., Амарантов Д.Г., Косарева П.В., 20172017Хоринко А.В., Амарантов Д.Г., Косарева П.В.Khorinko A.V., Amarantov D.G., Kosareva P.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://anatomy.elpub.ru/jour/article/view/307

Легкие являются одним из наиболее уязвимых органов для формирования фибропластических процессов вследствие наличия большого количества клеток-мишеней с ярко выраженными межклеточными взаимодействиями. Знание механизмов нарушения межклеточных взаимодействий и механизмов ремоделирования внеклеточного матрикса при пневмофиброзе различной этиологии лежит в основе разработки эффективных методов лечения этих заболеваний. На современном этапе важная роль отводится концепции эпителиально-мезенхимального перехода (ЭМП). Исследования идут в направлении поиска основных молекулярных посредников ЭМП - факторов роста, цитокинов. Тем не менее, в настоящее время неизвестно большинство ключевых моментов в реализации механизмов ЭМП. До настоящего времени не решен вопрос, является ли реваскуляризация патогенетическим механизмом, способствующим прогрессированию фиброза легких, или компенсаторным механизмом при повреждении ткани легкого. Анализ этих закономерностей открывает новые возможности терапии различных заболеваний, сопровождающихся пневмосклерозом.

Lungs are one of the most vulnerable for fibroplastic processes organs due to the presence of a large number of target cells with strong cell-cell interactions. Knowledge of the mechanisms of violation of intercellular interactions and mechanisms of the remodeling of extracellular matrix in fibrosis of various etiologies is the basis of the development of effective treatment for these diseases. At the present stage, an important role belongs to the concept of epithelial-mesenchymal transition (EMT). The studies extend in a direction of molecular mediators of EMT - growth factors, cytokines. However, at present the most key points in the implementation of EMT mechanisms are not known. Today, the issue is not resolved, revascularization is a pathogenic mechanism contributing to the progression of pulmonary fibrosis, or a compensatory mechanism in damaged lung tissue. The analysis of these regularities opens up new possibilities for the treatment of various diseases associated with pulmonary sclerosis.

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The authors declare that there are no conflicts of interest present.