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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">anatomy</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал анатомии и гистопатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Anatomy and Histopathology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2225-7357</issn><publisher><publisher-name>N.N. Burdenko Voronezh State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18499/2225-7357-2025-14-2-38-45</article-id><article-id custom-type="elpub" pub-id-type="custom">anatomy-2100</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>Особенности микроскопического строения энтезов пятой плюсневой кости мужчин первого периода зрелого возраста</article-title><trans-title-group xml:lang="en"><trans-title>Microscopic Structural Features of Fifth Metatarsal Bone Entheses in Men During the First Mature Age Period</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6002-0009</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дуков</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dukov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дуков Денис Владимирович – соискатель кафедры оперативной хирургии и топографической анатомии</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Denis V. Dukov – Applicant for the Department of Operative Surgery and Topographic Anatomy</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">denis_garant@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2548-8044</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Русских</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Russkikh</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Русских Андрей Николаевич – д-р. мед. наук, доцент, зав. кафедрой оперативной хирургии и топографической анатомии</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Andrei N. Russkikh – Doct. Sci. (Med.), Associate Professor, Head of Department of Operative Surgery and Topographic Anatomy</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">chegevara-84@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3462-962X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабоха</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabokha</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шабоха Анна Дмитриевна – канд. мед. наук, доцент кафедры оперативной хирургии и топографической анатомии</p><p>ул. Партизана Железняка, 1, Красноярск, 660022</p></bio><bio xml:lang="en"><p>Anna D. Shabokha – Cand. Sci. (Med.), Associate Professor of Department of Operative Surgery and Topographic Anatomy</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">tat_yak@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4438-1717</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алябьев</surname><given-names>Ф. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Alyab'ev</surname><given-names>F. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алябьев Федор Валерьевич – д-р. мед. наук, профессор, зав. кафедрой судебной медицины ИПО</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Fedor V. Alyab'ev – Doct. Sci. (Med.), Professor, Head ofForensic Medicine Department</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">alfedval@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9196-7246</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хоржевский</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khorzhevskii</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хоржевский Владимир Алексеевич – канд. мед. наук, зам. начальника по патолого-анатомической работе</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Vladimir A. Khorzhevskii – Cand. Sci. (Med.), Deputy Chief for Anatomic Pathology Services</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">vladpatholog@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-6190-049X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макаров</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarov</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макаров Александр Федорович – канд. мед. наук, врач травматолог-ортопед</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Aleksandr F. Makarov – Cand. Sci. (Med.), traumatologist-orthopedist</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">afmakaroff@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5889-8675</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яремин</surname><given-names>Б. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yaremin</surname><given-names>B. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Яремин Борис Иванович – канд. мед. наук, доцент кафедры трансплантологии и искусственных органов</p><p>Москва</p></bio><bio xml:lang="en"><p>Boris I. Yaremin – Cand. Sci. (Med.), Associate Professor of Transplantology and Artificial Organs Department</p><p>Moscow</p></bio><email xlink:type="simple">boris@yarem.in</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Красноярский государственный медицинский университет им. проф. В. Ф. Войно-Ясенецкого</institution></aff><aff xml:lang="en"><institution>V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Красноярское краевое патолого-анатомическое бюро</institution></aff><aff xml:lang="en"><institution>Krasnoyarsk Regional Bureau of Pathological Anatomy</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Красноярский центр пластической хирургии</institution></aff><aff xml:lang="en"><institution>Krasnoyarsk Center for Plastic Surgery</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы; Российский национальный медицинский университет им. Н.И. Пирогова</institution></aff><aff xml:lang="en"><institution>Sklifosovsky Research Institute For Emergency Medicine; N.I. Pirogov Russian National Research Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>07</month><year>2025</year></pub-date><volume>14</volume><issue>2</issue><fpage>38</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дуков Д.В., Русских А.Н., Шабоха А.Д., Алябьев Ф.В., Хоржевский В.А., Макаров А.Ф., Яремин Б.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Дуков Д.В., Русских А.Н., Шабоха А.Д., Алябьев Ф.В., Хоржевский В.А., Макаров А.Ф., Яремин Б.И.</copyright-holder><copyright-holder xml:lang="en">Dukov D.V., Russkikh A.N., Shabokha A.D., Alyab'ev F.V., Khorzhevskii V.A., Makarov A.F., Yaremin B.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://anatomy.elpub.ru/jour/article/view/2100">https://anatomy.elpub.ru/jour/article/view/2100</self-uri><abstract><p>Цель исследования – изучить особенности микроскопического строения энтезов V плюсневой кости у мужчин первого периода зрелого возраста. Материал и методы. Изучены особенности микроскопического строения энтезов пятой плюсневой кости обеих стоп трупов 56 мужчин в возрасте 21–35 лет. Гистологически исследованы образцы тканей мест типичного прикрепления связок и сухожилия к головке и основанию пятой плюсневой кости, окрашенных по методике К. Массона. Посредством световой микроскопии отсканированных гистотопограмм проводилось описание и измерение толщины зон энтезов с анализом расположения коллагеновых волокон и подсчетом их процентного содержания с окружающими образованиями. Результаты. Установлено, что соединения всех четырех связок и сухожилия пятой плюсневой кости по своей гистологической структуре являются фиброзно-хрящевыми энтезами с четырьмя отдельными зонами, структурно образующими непрерывный переход от соединительной ткани к костной. В результате исследования выявлено преобладание толщины зоны обызвествленного волокнистого хряща над толщиной зоны минерализованного волокнистого хряща энтезов сухожилия короткой малоберцовой мышцы, плюсневой подошвенной и коллатеральной связок с параллельным расположением извитых коллагеновых волокон и единичными зрелыми хондроцитами и их изогенными группами. Установлено максимальное значение толщины зоны обызвествленного волокнистого хряща энтеза глубокой поперечной плюсневой связки с прямым расположением коллагеновых волокон и множеством изогенных групп хондроцитов. Определена минимальная толщина зоны обызвествленного волокнистого хряща комплекса предплюсно-плюсневой и длинной подошвенной связок с хаотично-переплетенными коллагеновыми волокнами и множеством зрелых хондроцитов и их изогенных групп. Зарегистрированы зубчатые базофильные линии практически всех энтезов с преобладаем толщины и амплитуды зубцов линии у соединения сухожилия короткой малоберцовой мышцы, в сочетании со сглаженной и тонкой базофильной линией энтеза глубокой поперечной плюсневой связки. Установлено уменьшение доли коллагеновых волокон от обызвествленной зоны до минерализованной у энтезов сухожилия короткой малоберцовой мышцы и комплекса предплюсно-плюсневой и длинной подошвенных связок; увеличение доли коллагена в сторону минерализованной зоны у энтеза глубокой поперечной плюсневой связки и одинаковая его доля у энтезов плюсневой подошвенной и коллатеральной связок. Заключение. Проведенное исследование с обнаружением особенностей микроструктуры энтезов V плюсневой кости позволяет допустить существование возрастных, половых и конституциональных закономерностей их строения и предрасположенности к механической травме.</p></abstract><trans-abstract xml:lang="en"><p>The aim was to investigate the microscopic structural features of the entheses of the fifth metatarsal bone in men of the first mature age period. Material and methods. The study examined the microscopic features of the entheses of the fifth metatarsal bones bilaterally in 56 cadaveric specimens from males aged 21–35 years. Tissue specimens from the typical ligament and tendon attachment sites at the head and base of the fifth metatarsal bone were histologically analyzed using Masson’s trichrome staining. The thickness of enthesis zones was measured, and the organization of collagen fibers was analyzed with quantification of their percentage content in relation to adjacent structures using light microscopy of scanned histotopograms. Results. The study revealed that all four ligamentous and tendinous connections of the fifth metatarsal demonstrate fibrocartilaginous entheses comprising four distinct zones that structurally form a continuous transition from soft connective tissue to osseous tissue. Results showed greater thickness of the calcified versus mineralized fibrocartilage zones in the peroneus brevis tendon, plantar metatarsal, and collateral ligament entheses, featuring parallel wavy collagen fibers with scattered mature chondrocytes and isogenous groups. The maximal thickness of the calcified fibrocartilage zone was identified in the deep transverse metatarsal ligament enthesis, characterized by linearly oriented collagen fibers and abundant chondrocyte isogenous groups. The study determined the minimal thickness of the calcified fibrocartilage zone in the tarsometatarsal and long plantar ligament enthesis complex, exhibiting a disordered arrangement of collagen fibers and numerous mature chondrocytes organized in isogenous groups. Basophilic demarcation lines with serrated morphology in virtually all enthuses was documented. The most pronounced serrations (in both thickness and amplitude) were registered at the peroneus brevis tendon attachment site, while the deep transverse metatarsal ligament exhibited a characteristically attenuated and flattened basophilic line. A decreasing collagen gradient from calcified to mineralized zones was established in the peroneus brevis tendon and tarsometatarsal-long plantar ligament entheses, while the deep transverse metatarsal ligament exhibited an inverse pattern. The plantar metatarsal and collateral ligament entheses maintained equivalent collagen proportions across zones. Conclusion. The investigation of microarchitectural characteristics in fifth metatarsal entheses provides evidence supporting the probable existence of distinct structural patterns influenced by age, sex, and body constitution, which may correlate with differential susceptibility to mechanical trauma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мужчины</kwd><kwd>плюсневые кости</kwd><kwd>сухожилия</kwd><kwd>коллаген</kwd><kwd>фиброзно-хрящевые энтезы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>males</kwd><kwd>metatarsal bones</kwd><kwd>tendons</kwd><kwd>collagen</kwd><kwd>fibrocartilaginous entheses</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Баврина А.П. Современные правила использования методов описательной статистики в медико-биологических исследованиях. Медицинский альманах. 2020;63(2):95-105.</mixed-citation><mixed-citation xml:lang="en">Bavrina A.P. 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