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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">anatomy</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал анатомии и гистопатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Anatomy and Histopathology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2225-7357</issn><publisher><publisher-name>N.N. Burdenko Voronezh State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18499/2225-7357-2023-12-3-72-78</article-id><article-id custom-type="elpub" pub-id-type="custom">anatomy-1806</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>Гистотопографические особенности диафрагмы в норме и при ее метастатическом поражении</article-title><trans-title-group xml:lang="en"><trans-title>Histotopographical Features of the Diaphragm in Normal Conditions and with its Metastatic Lesions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5503-1598</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Просветов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Prosvetov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Просветов Вадим Алексеевич – соискатель кафедры нормальной анатомии</p><p>ул. академика Лебедева, 6, г. Санкт-Петербург, 194044</p></bio><bio xml:lang="en"><p>Vadim A. Prosvetov – researcher of the Department of Normal Anatomy</p><p>ul. Akademika Lebedeva, 6, St. Petersburg, 194044</p></bio><email xlink:type="simple">prosvetovvma@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7232-6419</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гайворонский</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaivoronskii</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гайворонский Иван Васильевич – д-р. мед. наук, профессор, зав. кафедрой нормальной анатомии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Ivan V. Gaivoronskii – Doct. Sci. (Med.), Professor, head the Department of Normal Anatomy</p><p>St. Petersburg</p></bio><email xlink:type="simple">i.v.gaivoronskiy@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4519-0018</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суров</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Surov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Суров Дмитрий Александрович – д-р. мед. наук, доцент, начальник кафедры военно-морской хирургии</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Dmitrii A. Surov – Doct. Sci. (Med.), Associate Professor, head of the Department of Naval Surgery</p><p>St. Petersburg</p></bio><email xlink:type="simple">sda120675@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3064-7596</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горячева</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Goryacheva</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горячева Инга Александровна – канд. мед. наук, доцент кафедры нормальной анатомии</p><p>Санкт-Петербург</p><p> </p></bio><bio xml:lang="en"><p>Inga A. Goryacheva – Cand. Sci. (Med.), Associate Professor of Normal Anatomy Department</p><p>St. Petersburg</p></bio><email xlink:type="simple">smoriarti@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Военно-медицинская академия им. С.М. Киров</institution></aff><aff xml:lang="en"><institution>S.M. Kirov Military Medical Academy</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Военно-медицинская академия им. С.М. Киров; Санкт-Петербургский государственный университет</institution></aff><aff xml:lang="en"><institution>S.M. Kirov Military Medical Academy; St. Petersburg State University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>06</day><month>10</month><year>2023</year></pub-date><volume>12</volume><issue>3</issue><fpage>72</fpage><lpage>78</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Просветов В.А., Гайворонский И.В., Суров Д.А., Горячева И.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Просветов В.А., Гайворонский И.В., Суров Д.А., Горячева И.А.</copyright-holder><copyright-holder xml:lang="en">Prosvetov V.A., Gaivoronskii I.V., Surov D.A., Goryacheva I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://anatomy.elpub.ru/jour/article/view/1806">https://anatomy.elpub.ru/jour/article/view/1806</self-uri><abstract><p>Изучение регионарных гистотопографических особенностей диафрагмы в норме и при различных вариантах метастатического поражения имеет прикладное значение в абдоминальной онкологии при планировании циторедуктивных оперативных вмешательств и диафрагмальной перитонэктомии.</p><p>Цель исследования – изучить гистотопографическое строение диафрагмы в норме и при перитонеальном карциноматозе.</p><sec><title>Материал и методы</title><p>Материал и методы. Проведено изучение 40 небальзамированных препаратов диафрагмы, из которых были изготовлены гистотопограммы ее различных отделов. Также был изучен операционный материал 77 пациентов, перенесших циторедуктивное вмешательство и диафрагмальную перитонэктомию различного объема и изготовлены гистологические препараты. Проводилось изучение регионарных гистотопографических особенностей диафрагмы в норме и при ее метастатическом поражении. Был проведен корреляционный анализ размеров карциноматозных узлов и глубины опухолевой инвазии.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что гистотопографическое строение в различных отделах диафрагмы в норме специфично и имеет ряд отличий. Метастатическое поражение диафрагмы при перитонеальном карциноматозе различается по размеру опухолевых узлов, глубине опухолевой инвазии, сочетанному поражению смежных анатомических структур. В большинстве случаев размер карциноматозных поражений напрямую коррелировал с глубиной опухолевой инвазии, однако, установлено, что ряд крупных опухолевых узлов не имеет такой глубины прорастания, а поражает лишь поверхностные слои диафрагмы (брюшину  и  диафрагмальную  фасцию).</p></sec><sec><title>Заключение</title><p>Заключение.  Результаты  изучения  глубины  опухолевой  инвазии, зачастую имеющей связь с размером карциноматозных узлов, могут быть внедрены в клиническую практику  при  планировании  циторедуктивных  оперативных  вмешательств  и  выполнении  диафрагмальной перитонэктомии.</p></sec></abstract><trans-abstract xml:lang="en"><p>The study of regional histotopographic features of the diaphragm in normal conditions and in various types of metastatic lesions is of practical importance in abdominal oncology when planning cytoreductive surgical interventions and diaphragmatic peritonectomy.</p><p>The aim was to study the histotopographic structure of the diaphragm in normal and peritoneal carcinomatosis.</p><sec><title>Material and methods</title><p>Material and methods. 40 non-embalmed preparations of the cadaveric diaphragm were used to prepare histotopograms of their various parts. The surgical material of 77 patients who underwent cytoreductive intervention and diaphragmatic peritonectomy of various volumes was also studied and histological preparations were made. Regional histotopographic features of the diaphragm in normal and metastatic lesions were studied. A correlation analysis of the size of carcinomatous nodes and the depth of tumor invasion was carried out.</p></sec><sec><title>Results</title><p>Results. It was found that the histotopographic structure in various parts of the diaphragm is normally specific and has a number of differences. Metastatic damage to the diaphragm in peritoneal carcinomatosis differs in size of tumor nodes, in depth of tumor invasion, and in combined lesion of adjacent anatomical structures. In most cases, the size of carcinomatous lesions directly correlated with the depth of tumor invasion, however, it was found that a number of large tumor nodes do not have such   a   depth   of   germination,   but   affect   only   the   superficial   layers of   the   diaphragm (peritoneum and  diaphragmatic fascia).</p></sec><sec><title>Conclusion</title><p>Conclusion. The results of studying the depth of tumor invasion, which is often associated with the size of carcinomatous nodes, can be implemented in clinical practice when planning cytoreductive surgical interventions and performing diaphragmatic peritonectomy.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>диафрагма</kwd><kwd>гистотопограммы</kwd><kwd>перитонеальный карциноматоз</kwd><kwd>циторедуктивная хирургия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diaphragm</kwd><kwd>histotopograms</kwd><kwd>peritoneal carcinomatosis</kwd><kwd>cytoreductive surgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ганцев Ш.Х., Соломенный С.В., Ганцев К.Ш., Кзыргалин Ш.Р., Минигазимов Р.С., Логинова М.В.. Оценка состояния серозно лимфатических люков при перитонеальном канцероматозе по данным сканирующей электронной микроскопии (на примере диафрагмальной брюшины). Креативная хирургия и онкология. 2014;4:4–10.</mixed-citation><mixed-citation xml:lang="en">Gantsev  ShKh.,  Solomenny  SV,  Gantsev  KSh, Kzyrgalin  ShR,  Minigazimov  RS,  Loginova  MV. Assessment  Of  Serous  Lymph  Hatches  In Peritoneal Carcinomatosis  (Diaphragmatic Peritoneum)  By  Scanning  Electron  Microscopy. Creative  surgery  and  oncology.  2021;11(2):149-156. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ганцев Ш.Х., Ганцев К.Ш., Кзыргалин Ш.Р., Ишмуратова К.Р. Перитонеальный канцероматоз при злокачественных новообразованиях различных локализаций. Достижения и перспективы. Креативная хирургия и онкология. 2021;11(2):149-156. doi:10.24060/2076-3093-2021-11-2-149-156</mixed-citation><mixed-citation xml:lang="en">Gantsev  SK,  Gantsev  KS,  Kzyrgalin  SR, Ishmuratova  KR.  Peritoneal  Canceromatosis  in Malignant  Tumors  of  Various  Localizations. Achievements and Prospects. Creative surgery and oncology.  2021;11(2):149-156.  (In  Russ.)  doi: 10.24060/2076-3093-2021-11-2-149-156</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Craus-Miguel A, Segura-Sampedro JJ, González-Argenté X, Morales-Soriano R. Diaphragmatic Peritonectomy and Full-Thickness Resection in CRS/HIPEC May Allow Higher Completeness of Cytoreduction Rates with a Low Rate of Respiratory Complications. Ann Surg Oncol. 2021 Aug;28(8):4676–82. doi: 10.1245/s10434-020-09505-3. Epub 2021 Jan 6. PMID: 33409735.</mixed-citation><mixed-citation xml:lang="en">Craus-Miguel  A,  Segura-Sampedro  JJ,  González-Argenté  X,  Morales-Soriano  R.  Diaphragmatic Peritonectomy  and  Full-Thickness  Resection  in CRS/HIPEC  May  Allow  Higher  Completeness  of Cytoreduction  Rates  with  a  Low  Rate  of Respiratory Complications. Ann Surg Oncol. 2021 Aug;28(8):4676–82.  doi: 10.1245/s10434-020-09505-3. Epub 2021 Jan 6. PMID: 33409735.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Halkia E, Efstathiou E, Spiliotis J, Romanidis K, Salmas M. Management of diaphragmatic peritoneal carcinomatosis: surgical anatomy guidelines and results. J BUON. 2014 Jan-Mar;19(1):29-33. PMID: 24659639.</mixed-citation><mixed-citation xml:lang="en">Halkia  E,  Efstathiou E,  Spiliotis  J,  Romanidis  K, Salmas  M.  Management  of  diaphragmatic peritoneal  carcinomatosis:  surgical  anatomy guidelines  and  results.  J  BUON.  2014  Jan-Mar;19(1):29-33. PMID: 24659639.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ishii T, Seo S, Ito T, Ogiso S, Fukumitsu K, Taura K, Kaido T, Uemoto S. Structure and surgical dissection layers of the bare area of the liver. BMC Surg. 2020 Jul 31;20(1):172. doi: 10.1186/s12893-020-00830-8. PMID: 32736550; PMCID: PMC7393883.</mixed-citation><mixed-citation xml:lang="en">Ishii T, Seo S, Ito T, Ogiso S, Fukumitsu K, Taura K,  Kaido  T,  Uemoto  S.  Structure  and  surgical dissection layers of the bare area of the liver. BMC Surg. 2020 Jul 31;20(1):172. doi: 10.1186/s12893-020-00830-8.  PMID:  32736550;  PMCID: PMC7393883.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Papadia A, Morotti M. Diaphragmatic surgery during cytoreduction for primary or recurrent epithelial ovarian cancer: a review of the literature. Arch Gynecol Obstet. 2013 Apr;287(4):733-41. doi: 10.1007/s00404-013-2715-1. Epub 2013 Jan 23. PMID: 23341061.</mixed-citation><mixed-citation xml:lang="en">Papadia  A,  Morotti  M.  Diaphragmatic  surgery during  cytoreduction  for  primary  or  recurrent epithelial  ovarian  cancer:  a  review  of  the literature. Arch Gynecol Obstet.  2013 Apr;287(4):733-41.  doi: 10.1007/s00404-013-2715-1. Epub 2013 Jan 23. PMID: 23341061.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Stepanyan A, Zhirayr Malakyan, Alaverdyan A, Davtyan H, Hovhannisyan T. Right upper quadrant peritonectomy. Answering frequently asked questions. Int J Gynecol Cancer. 2021 Sep 1;31(9):1305–6. doi: 10.1136/ijgc-2021-002695</mixed-citation><mixed-citation xml:lang="en">Stepanyan  A,  Zhirayr  Malakyan,  Alaverdyan  A, Davtyan  H,  Hovhannisyan  T.  Right  upper quadrant  peritonectomy.  Answering  frequently asked  questions.  Int  J  Gynecol  Cancer.  2021  Sep 1;31(9):1305–6. doi: 10.1136/ijgc-2021-002695</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tozzi R, Ferrari F, Joost Nieuwstad, Riccardo Garruto Campanile, Hooman Soleymani Majd. Tozzi classification of diaphragmatic surgery in patients with stage IIIC–IV ovarian cancer based on surgical findings and complexity. J Gynecol Oncol. 2020 Jan 1;31(2):2. doi: 10.3802/jgo.2020.31.e14</mixed-citation><mixed-citation xml:lang="en">Tozzi  R,  Ferrari  F,  Joost  Nieuwstad,  Riccardo Garruto  Campanile,  Hooman  Soleymani  Majd. Tozzi  classification  of  diaphragmatic  surgery  in patients with stage IIIC–IV ovarian cancer based on  surgical  findings  and  complexity.  J  Gynecol Oncol.  2020  Jan 1;31(2):2. doi: 10.3802/jgo.2020.31.e14</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zapardiel I, Peiretti M, Zanagnolo V, Biffi R, Bocciolone L, Landoni F, et al. Diaphragmatic Surgery During Primary Cytoreduction for Advanced Ovarian Cancer: Peritoneal Stripping Versus Diaphragmatic Resection. International Journal of Gynecologic Cancer. 2011 Nov;21(9):1698–703. Doi Nov;21(9):1698–703. doi: 10.1097/igc.0b013e31822f65c3</mixed-citation><mixed-citation xml:lang="en">Zapardiel  I,  Peiretti  M,  Zanagnolo  V,  Biffi  R, Bocciolone  L,  Landoni  F,  et  al.  Diaphragmatic Surgery  During  Primary  Cytoreduction  for Advanced  Ovarian  Cancer:  Peritoneal  Stripping Versus  Diaphragmatic  Resection.  International Journal of  Gynecologic Cancer.  2011 Nov;21(9):1698–703. Doi Nov;21(9):1698–703. doi: 10.1097/igc.0b013e31822f65c3</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
