anatomyЖурнал анатомии и гистопатологииJournal of Anatomy and Histopathology2225-7357N.N. Burdenko Voronezh State Medical University10.18499/2225-7357-2021-10-2-73-79anatomy-1315Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESФункциональная морфология бокаловидных клеток тонкой кишки при действии различных факторовFunctional Morphology of Goblet Cells of the Small Intestine under the Influence of Various FactorsШараповИ. Ю.SharapovI. Yu.

Шарапов Илья Юрьевич

  ул.  Студенческая,  10,  Воронеж, 394036

Il'ya Sharapov

 ul.  Studencheskaya, 10, Voronezh, 394036

anat-vrn@yandex.ruКварацхелиияА. Г.KvaratskheliiyaA. G.БолгучеваМ. Б.BolguchevaM. B.КороткихК. Н.KorotkikhK. N.ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России, ВоронежРоссияN.N. Burdenko Voronezh State Medical University, VoronezhRussian FederationФГБОУ ВО «Ингушский государственный университет», МагасИндияIngush State University, MagasIndia2021150720211027379Copyright © Шарапов И.Ю., Кварацхелиия А.Г., Болгучева М.Б., Коротких К.Н., 20212021Шарапов И.Ю., Кварацхелиия А.Г., Болгучева М.Б., Коротких К.Н.Sharapov I.Y., Kvaratskheliiya A.G., Bolgucheva M.B., Korotkikh K.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://anatomy.elpub.ru/jour/article/view/1315

Желудочно-кишечный тракт постоянно подвергается воздействию различных физических и химических  факторов.  В  кишечнике  контакт  бактерий  с  эпителиоцитами  в  значительной  степени  зависит  от слизи, которая в основном состоит из высоко  гликозилированного муцина-2, секретируемого бокаловидными клетками эпителия слизистой. Бокаловидные клетки располагаются по всей длине тонкой и толстой кишки и отвечают за выработку и поддержание защитного слоя слизи путем синтеза и секрециивысоко-молекулярных  гликопротеинов,  известных  как  муцины.  В  статье  представлены  данные  об  эмбриогенезе тонкой  кишки  в целом  и,  бокаловидных  клеток,  в частности;  представлен  литературный обзор, раскрывающий роль бокаловидных клеток в морфофункциональной организации кишечного тракта и функциональной  активности  их  секрета.  Ввиду  особенностей  этих  сильно  поляризованных  экзокринных  клеток обсуждаются клеточные механизмы, с помощью которых бокаловидные клетки секретируют свои продукты.

The gastrointestinal tract is constantly exposed to various physical and chemical factors. In the intestine, the contact of bacteria and the epithelium largely depends on mucus, which mainly consists of highly glycosylated mucin-2 secreted by goblet cells in the epithelium. Goblet cells are located along the entire length of the small and large intestine and are responsible for the production and maintenance of a protective layer of mucus through the synthesis and secretion of high-molecular glycoproteins known as mucins. The article presents data on the embryogenesis of the small intestine in general and goblet cells, in particular, a literary review of the role of goblet cells in the morphology of the intestinal tract, the functional aсtivity of their secretion is carried out. Due to the unique nature of this highly polarized exocrine cell, the cellular mechanisms by which goblet cells  secrete their products are discussed.

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The authors declare that there are no conflicts of interest present.